If you have good control over diabetes then the good news is that HBA1C can drop by 10%. But if your levels are higher than 7.5 then the drop is slower.
Contents
Can A1C change in 3 months?
But if you’ve gone completely off your meal plan for several weeks or longer, your A1C will probably be higher. Since the A1C test measures your blood glucose levels for the past 2 to 3 months, a good rule of thumb is to expect that it will take the same amount of time to see significant changes.
What is considered a significant drop in A1C?
A change (either positive or negative) in A1C percentage of 0.5% is considered clinically significant.
How quickly can HbA1c decrease?
What is HbA1c? – HbA1c (glycosylated haemoglobin) is a measure of the amount of glucose attached to the body’s red blood cells; it is present in everyone. It gives an indication of your blood glucose control over the last 2-3 months. The level of HbA1c in your body rises and falls in line with your blood glucose – the higher your HbA1c, the more glucose is attached to your red blood cells.
- Your HbA1c does not change rapidly because the red blood cells in your circulation last for around 3-4 months.
- Any increases and decreases in your HbA1c will happen over a period of at least 6 weeks.
- HbA1c is recorded as mmol/mol, and sometimes as a percentage, while blood glucose is recorded in mmol/L.
You may be used to seeing your HbA1c reported as a percentage, however from 1 October 2011, HbA1c changed to be given in mmol/mol. An HbA1c test is not the same as a blood glucose test.
Can HbA1c 6.9 be reversed?
Type-2 diabetes is reversible! Type-2 diabetes is said to be reversed (in remission) when your HbA1c remains below 6.5% (or. This reversal of diabetes remains possible for at least 10 years after the onset of the condition.
How many months does A1C go back?
All About Your A1C What has your blood sugar been up to lately? Get an A1C test to find out your average levels—important to know if you’re at risk for prediabetes or type 2 diabetes, or if you’re managing diabetes. The A1C test—also known as the hemoglobin A1C or HbA1c test—is a simple blood test that measures your average blood sugar levels over the past 3 months.
It’s one of the commonly used tests to diagnose and and is also the main test to help you and your health care team manage your diabetes. Higher A1C levels are linked to diabetes complications, so reaching and maintaining your individual A1C goal is really important if you have diabetes. When sugar enters your bloodstream, it attaches to hemoglobin, a protein in your red blood cells.
Everybody has some sugar attached to their hemoglobin, but people with higher blood sugar levels have more. The A1C test measures the percentage of your red blood cells that have sugar-coated hemoglobin. Testing for diabetes or prediabetes: Get a baseline A1C test if you’re an adult over age 45—or if you’re under 45, are overweight, and have one or more for prediabetes or type 2 diabetes:
If your result is normal but you’re over 45, have risk factors, or have ever had gestational diabetes, repeat the A1C test every 3 years. If your result shows you have prediabetes, talk to your doctor about taking steps now to improve your health and lower your risk for type 2 diabetes. Repeat the A1C test as often as your doctor recommends, usually every 1 to 2 years. If you don’t have but your result shows you have prediabetes or diabetes, get a second test on a different day to confirm the result. If your test shows you have diabetes, ask your doctor to refer you to services so you can have the best start in managing your diabetes.
Managing diabetes : If you have diabetes, get an A1C test at least twice a year, more often if your medicine changes or if you have other health conditions. Talk to your doctor about how often is right for you. The test is done in a doctor’s office or a lab using a sample of blood from a finger stick or from your arm.
Normal | Below 5.7% |
---|---|
Prediabetes | 5.7% to 6.4% |
Diabetes | 6.5% or above |
A normal A1C level is below 5.7%, a level of 5.7% to 6.4% indicates prediabetes, and a level of 6.5% or more indicates diabetes. Within the 5.7% to 6.4% prediabetes range, the higher your A1C, the greater your risk is for developing type 2 diabetes. Managing Diabetes Your A1C result can also be reported as estimated average glucose (eAG), the same numbers (mg/dL) you’re used to seeing on your blood sugar meter:
A1C % | eAG mg/dL |
---|---|
7 | 154 |
8 | 183 |
9 | 212 |
10 | 240 |
Get your A1C tested in addition to—not instead of—regular blood sugar self-testing if you have diabetes. Several factors can falsely increase or decrease your A1C result, including:
Kidney failure, liver disease, or severe anemia. A less common type of hemoglobin that people of African, Mediterranean, or Southeast Asian descent and people with certain blood disorders (such as sickle cell anemia or thalassemia) may have. Certain medicines, including opioids and some HIV medications. Blood loss or blood transfusions. Early or late pregnancy.
Let your doctor know if any of these factors apply to you, and ask if you need additional tests to find out. The goal for most people with diabetes is 7% or less. However, your personal goal will depend on many things such as your age and any other medical conditions. Work with your doctor to set your own individual A1C goal. Younger people have more years with diabetes ahead, so their goal may be lower to reduce the risk of complications, unless they often have hypoglycemia (low blood sugar, or a “low”). People who are older, have severe lows, or have other serious health problems may have a higher goal. A1C is an important tool for managing diabetes, but it doesn’t replace regular blood sugar testing at home. Blood sugar goes up and down throughout the day and night, which isn’t captured by your A1C. Two people can have the same A1C, one with steady blood sugar levels and the other with high and low swings. If you’re reaching your A1C goal but having symptoms of highs or lows, check your blood sugar more often and at different times of day. Keep track and share the results with your doctor so you can make changes to your treatment plan if needed. : All About Your A1C
How much can A1C drop in 2 months?
How quickly can you lower your A1c? – Because A1c is simply a measure of your average blood sugar over 2-3 months, it can (in theory) decrease by any amount over that time period. If you, from one day to the next, decreased your daily average blood sugar from 300 mg/dl (16.7 mmol/l) to 120 mg/dl (6.7 mmol/l), your A1c would decrease from 12% to 6% in around two months.
Is A1C of 7.5 average blood sugar?
An A1c higher than 9% – However, numbers much higher than 9% can start to put you at risk for diabetes complications later on in life. According to the American Diabetes Association’s Standards of Medical Care in Diabetes, 2022, an A1c of 9% puts one at a higher risk for blindness, heart attack, nerve damage, and kidney failure.
An A1c is 9% is equal to an average blood sugar level of 212 mg/dL. The higher your A1c, the more dangerous it is and the more likely you are to suffer from diabetes complications. The following are A1c levels to average blood sugar levels: 10 % = 240 mg/dL 11% = 269 mg/dL 12% = 298 mg/dL 13% = 326 mg/dL 14% = 355 mg/dL For more detailed information, read How to Translate Your A1c to a Blood Sugar Level,
Prolonged high blood sugars over time can lead to severe diabetes complications, such as retinopathy, neuropathy, heart disease, kidney disease, lower-limb amputations, stroke, and even premature death. If you’re struggling to lower your A1c, talk to your doctor about increasing or changing your medication regimen, diet, physical activity level, addressing any mental health issues, or if they suggest other ways to help you better manage your blood sugar levels.
Is 5.2 a good A1C?
CONCLUSION – Hemoglobin A1c has come to play an important role in the diagnosis of diabetes. We found that patients with HbA1c values lower than 5.2% can be diagnosed as “healthy”, values from 5.2% to 6.4% as having “prediabetes,” and a value >6.4% as having “diabetes”. Since handling patients with different disease categories may involve some variation, it is important to determine with high confidence at which disease state a patient is. Our single center experience showed that the performance of HbA1c in distinguishing between prediabetes and diabetes groups is stronger than in distinguishing between healthy and prediabetes groups, According to the HbA1c test, misclassification of the subject with diabetes as prediabetes is more important than the misclassification of the healthy subject as prediabetes in terms of changing the frequency of follow-up and treatment strategy. Furthermore, if the subject with prediabetes was diagnosed as healthy, his clinical follow-up might be skipped. Therefore, if a subject was diagnosed as healthy or prediabetes by HbA1c, it would be beneficial to verify the status of that subject by the gold standard test (OGTT and FPG). These findings need to be confirmed in larger studies. Validation of this study should be investigated by further research.
Is lower A1C always better?
But what do these results mean for you? – For you, a person with type 1 diabetes, lowering your A1C by 1 per cent means a 45 per cent less risk you will develop the chronic complications of diabetes! That’s 45 per cent for each 1 per cent lower! The closer to normal (<6 per cent) the A1C is the better! The results also mean that an A1C of <7 per cent will also be good for you if you already have some signs of chronic complications. For example, kidney and eye disease may stay stable for years! At the end of the original DCCT trial, all the people in the conventional group changed to intensive therapy and their A1C lowered. Then both groups went back to their usual diabetes care teams, coming back to the study centre for a once yearly assessment. This same group of volunteers has remained in the DCCT follow up study called Epidemiology of Diabetes Interventions & Complications (EDIC) since 1993. Now that's commitment to a research study! Over time the A1C of the original intensive therapy and the former conventional therapy groups evened out at an average of 8%, but the benefits of intensive therapy remained – much to everyone's surprise. And for the first time, the benefits of good control on heart/cardiovascular disease were clearly shown.
Can my A1C go back to normal?
When you have diabetes, you probably know you should check your blood sugar regularly. Your doctor will also recommend that you take an A1c blood test a few times a year, with a goal of lowering the results to help protect your health. And there’s a lot you can do to move toward meeting that goal.
Unlike a regular blood sugar test, the A1c test measures the amount of sugar that clings to a protein, called hemoglobin, in your red blood cells. The test shows your average blood sugar levels over the past few months, so you know how well your diabetes is under control. In general, the goal for your A1c is to be lower than 7%.
Exactly how much lower will depend on your individual treatment plan. When you take steps to get your A1c in a healthy range, you lower your risk of complications such as nerve damage, eye problems, and heart disease, Your doctor will let you know the best target for your A1c.
How do you get there? Here are a few tactics to try, in addition to taking any medications your doctor prescribes. Get some new kitchen gear. You’ll want to get a set of measuring cups and a kitchen scale if you don’t already have them. These will help you with your portion sizes, Your blood sugar will go up if you eat more food than your body needs.
Keeping servings in check is a good way to reduce your A1c level. At first, it’s a good idea to measure your food to give you an idea of what healthy portion sizes look like for different foods. That’s where the measuring cups and scale come in handy. You may be surprised at first to see what one serving looks like, especially of high-carb items like cereal, rice, and pasta.
- But this will help ensure you don’t eat more than you intend to.
- Be carb smart.
- It’s true that carbohydrates affect your blood sugar more than other nutrients you eat.
- Chances are that if you overdo starchy carbs on a regular basis, your A1c number will start to creep up.
- But remember, all carbs aren’t a problem.
You want ones that have a lot of fiber and nutrients, more than those that just serve up starch. Tweak your plate, Experts advise filling about half your plate with vegetables that are low in starch, such as carrots, greens, zucchini, or tomatoes, One-quarter of your plate should be a lean protein like chicken or tofu, and the last quarter should be whole grains like brown rice or quinoa.
Make a plan. The guidelines for what to put on your plate give you a lot of flexibility. But even though it sounds simple, you’ll probably be better off if you plan your meals. Why? If you skip set menus and eat on the fly, it’s easy to end up with calorie-dense, high- carbohydrate food choices – like fast food, bagels, and frozen pizza – that will cause your blood sugar and A1c numbers to soar.
Instead, at the start of each week, pencil in a rough plan for what foods you’ll eat at each meal and what groceries you’ll need. This way, you’ll be prepared with plenty of choices that limit post-meal blood sugar spikes. A Mediterranean diet, which is low in saturated fat and high in vegetables and fruit, reliably lowers A1c numbers.
Maybe downsize your weight loss goal, Not everyone with type 2 diabetes is overweight, But if you are, you may not need to drop as much as you think to make a difference in your A1c level. If you’re overweight, diabetes doctors will often recommend you try to lose just 5% to 10% of your current weight.
Here’s why: As you shed extra pounds, the insulin in your body lowers your blood sugar levels more efficiently, which will cause your A1c levels to drop over time. In one study, people with type 2 diabetes who lost 5% to 10% of their body weight were three times as likely to lower their A1c by 0.5%.
You may have a different goal for your weight or other health considerations on your mind. Ask your doctor to help you make a weight loss plan that matches your overall goals. Rethink your exercise plan, Other than upgrading your nutrition, exercise is one of the most important habit changes you can make to lower your A1c.
But don’t just grind it out on the treadmill, or you’ll miss another effective workout: strength training, No offense to the elliptical machine or your cycling class. You can choose whatever type of exercise you prefer as long as it’s a challenging workout.
Both aerobic exercise and resistance (weight) training lower A1c levels if they’re part of a regular routine. There’s solid science to support how much working out helps you whittle down your A1c level. Since exercise prompts your muscles to take up sugar from your bloodstream, it helps your blood sugar levels drop more quickly after you eat a meal.
As you make exercise a regular habit, you’ll see a downward trend in your A1c numbers. Never miss your meds, You can reliably lower your A1c through diet and exercise. But if your doctor has prescribed medication, such as metformin, miglitol, or insulin, it’s important to take them exactly as prescribed.
If you miss doses regularly, your blood sugar numbers may creep up and cause your A1c to rise. But if you follow the medication plan that your doctor recommends and go to every appointment, your blood sugar should stay under control – and your lower A1c number will reflect that. If your goal is to cut down on, or even stop needing, your meds, tell your doctor that you want to work toward that.
But don’t stop them on your own. Be savvy about supplements, Many dietary supplements say they’ll lower your A1c. But there’s not always much research to back that up. Still, some may have promise. These include berberine, made up of extracts from a variety of plants, and coenzyme Q10 (CoQ10), an antioxidant that reduces inflammation in your body.
Cinnamon may also lower A1c levels over time. As with any supplement, it’s best to check with your doctor first. Put your plan on repeat. Stick with it and give it time. Since your A1c level reflects your average blood sugar over several months, it’s going to take that long for your A1c to drop. You won’t do everything perfectly, and that’s OK.
Just keep moving in the direction you want to go in. And rest assured: Your A1c number will come down, and it’ll be worth it.
Can HbA1c change in 2 weeks?
Hemoglobin A1c – Hemoglobin A1c (HbA1c) refers to a minor population of HbA that has been modified by attachment of glucose to the N-terminal amino acid of the beta globin chain. Since erythrocytes are freely permeable to glucose, the attachment occurs continually over the entire lifespan of the erythrocyte and is dependent on glucose concentration and the duration of exposure of the erythrocyte to blood glucose. HbA1c is a weighted average of blood glucose levels during the preceding 120 days, which is the average life span of red blood cells. A large change in mean blood glucose can increase HbA1c levels within 1-2 weeks. Sudden changes in HbA1c may occur because recent changes in blood glucose levels contribute relatively more to the final HbA1c levels than earlier events.
For instance, mean blood glucose levels in the 30 days immediately preceding blood sampling contribute 50% to the HbA1c level, whereas glucose levels in the preceding 90-120 day period contribute only 10%. Thus, it does not take 120 days to detect a clinically meaningful change in HbA1c following a significant change in mean plasma glucose level.
Hemoglobin A1c Methods Methods for analysis of HbA1c can essentially be divided into 2 categories depending on whether they measure HbA1c based upon charge or structure. The most common charge-based method utilizes cation-exchange high pressure liquid chromatography (HPLC).
In this method, different hemoglobin molecules (eg, HbA, HbA2, HbF) are eluted from the column at different times following exposure to buffers of increasing ionic strength, depending on their charge. HbA1c is less positively charged than HbA and does not bind as tightly to the negatively charged resin.
Therefore, it elutes more rapidly than HbA. The quantity of each Hb fraction in the eluate is quantitated by spectrophotometry and expressed as a percentage. Structural methods include boronate-affinity chromatography and immunoassays. Boronate-affinity chromatography is based on the strong bindng of the coplanar cis-diol groups on glycated hemoglobin with boronic acid residues attached to the chromatography resin.
Nonglycated Hb does not bind to boronic acid and elute immediately. Glycated Hb bind to boronic acid and must be eluted by a counterligand. This method measures total glycated hemoglobin, including HbA1c and Hb glycated at the epsilon amino groups on lysine. It must be calibrated using HbA1c specific values to produce HbA1c equivalent values.
Most immunoassays use polyclonal or monoclonal antibodies that recognize the β-N-terminal glycated amino acid in the first 4 to 10 amino acids of beta globin. The final concentration is calculated as a ratio of HbA1c to total hemoglobin. Hemoglobin Variants More than 950 different hemoglobin variants have been identified.
- In the United States, hemoglobin S is the most common variant, followed by hemoglobin C, hemoglobin E, and hemoglobin D (Punjab/Los Angeles).
- Worldwide, hemoglobin variants follow this same trend, except that hemoglobin E is more common than C.
- Hemoglobin variants that produce changes in the charge or structure of the hemoglobin molecule may affect the accuracy of HbA1c measurement.
In general, charge-based methods are more susceptible to interference from hemoglobin variants than immunoassays. Boronate-affinity chromatography is the least affected by hemoglobin variants. Situations that may suggest interference with HbA1c measurement due to a hemoglobin variant include:
Poor correlation of self-blood glucose monitoring with A1C results A HbA1c result different than expected A HbA1c result greater than 15% A HbA1C result differing significantly from a previous result obtained with a different method
The following table lists the methods most often used to measure A1C and whether the method is affected by HbS, HbC, HbE, HbD, or HbF.
Interference from | |||||
Method | HbS | HbC | HbE | HbD | Hb F |
Abbott Architect | No | No | No | No | $ |
Alere Afinion | No | No | No | No | $ |
Beckman Unicel | No | No | No | No | $ |
Bio-Rad D-100 | No | No | No | No | $ |
Bio-Rad Variant II Turbo | No | No | No | No | No <25% |
Ortho-Clinical Vitros | No | No | No | No | $ |
Roche Cobas c513 | No | No | No | No | $ |
Roche/Hitachi (Tina Quant II) | No | No | No | No | $ |
Sebia Capillarys 2 | No | No | No | No | No <15% |
Siemens Atellica | No | No | No | No | $ |
Siemens DCA Vantage | No | Yes | Yes | No | No <10% |
Siemens Dimension | No | No | No | No | $ |
Tosoh G8 | No | No | No | No | No <30% |
Trinity HPLC | No | No | No | No | No <15% |
Modified from http://www.ngsp.org/interf.asp In the absence of specific method data, it can generally be assumed that both immunoassay and boronate affinity methods show interference from HbF levels above 10-15% If a patient has one of these hemoglobin variants, their HbA1c level should be measured using a method that does not show interference from the variant. Patients with serious hemoglobinopathies (such as homozygous S or C) may have inaccurate HbA1c levels due to shortened red cell lifespan. In these cases, an alternative test of glycemia, such as fructosamine (also called glycated serum protein or glycated albumin) may be substituted. Serum proteins show average glucose levels over a much shorter period of time than the A1C test, usually about 2 to 3 weeks. Moreover, the fructosamine test has not been standardized and the relationship of results of this test to glucose levels or risk for complications has not been established Conditions that affect HbA1c Level Hemodilution and increased red cell turnover decrease HbA1c concentration during pregnancy. Iron deficiency can increase HbA1c level during the last trimester due to decreased cell turnover. Hemolytic anemia and blood loss anemia decrease HbA1c level due to the release of reticulocytes whose hemoglobin is not glycosylated. Transfusion of diabetic patients with red blood cells decreases their HbA1c concentration. Patients with asplenia have higher HbA1c levels due to increased circulating life span of red blood cells. Iron deficiency increases HbA1c, but iron replacement therapy increases reticulocytosis and decreases HbA1c concentration. Vitamin B12 deficiency also decreases red cell turnover and increase HbA1c level. Patients with renal failure have misleadingly low HbA1c levels due to shortened red cell survival and the use of recombinant erythropoietin, which increases reticulocytosis. Chronic alcohol, salicylate and opiate use have all been reported to falsely increase HbA1c levels. Drugs that cause hemolysis can lower HbA1c concentration. Examples include dapsone, ribavirin and sulfonamides. Hydroxyurea converts hemoglobin A to F, thereby lowering HbA1c. Clinical Use HbA1c provides a much better indication of long-term glycemic control than blood and urinary glucose determinations. There is broad consensus that HbA1c levels should be used for routine care of all patients with diabetes mellitus. Baseline HbA1c levels are strongly related to the incidence and/or progression of retinopathy, gross proteinuria, and loss of tactile sensation or temperature sensitivity. In the 2009 American Diabetes Association (ADA) Summary of Revisions for the Clinical Practice Recommendations, the HbA1c goal for nonpregnant adults is <7% (Diabetes Care 2009;32(S1):S3-S5). Currently, the American Diabetes Association (ADA) advocates that all individuals at high risk for diabetes be screened at least every 3 years. All persons 45 years and older are considered to be at high risk. ADA also recommends measurement of HbA1c three to four times per year for type 1 and poorly controlled type 2 diabetic patients, and 2 times per year for well-controlled type 2 diabetic patients. This is a general guideline to reduce the risk of microvascular and neuropathic complications. Physicians may need to individualize testing for certain patients. The Office of Inspector General (OIG) has released its Fiscal Year 2011 Work Plan, which describes the investigative, enforcement and compliance activities that it will undertake in the coming year. OIG will review Medicare contractors for screening the frequency of clinical laboratory claims for HbA1c and determine the appropriateness of Medicare payments. The following testing intervals are considered medically necessary:
Every 3 months to monitor a diabetic patient’s metabolic control Every 1-2 months when treatment regimen is altered to improve control Every month for diabetic pregnant women Patients with uncontrolled type I or II diabetes may be tested more frequently if the medical record contains supportive documentation
An Advance Beneficiary Notice (ABN) should be submitted for Medicare patients whenever a HbA1c is ordered at more frequent intervals than those listed above. HbA1c for Diagnosis of Diabetes Hyperglycemia has been the sole diagnostic criterion for diabetes since the development of blood glucose assays 100 years ago.
8-12 hour fasting specimen requirement Diurnal variation requiring morning collection to capture peak levels Large biological variation of 5-8% Nonstandardized instrument methods with >12% bias Glycolysis after collection, even in sodium fluoride tubes
In 2009, an International Expert Committee recommended the use of the HbA1c test to diagnose diabetes, with a threshold of 6.5% or greater (Diabetes Care 2009, 32 (7):1327-1334). The American Diabetes Association adopted this criterion in 2010. The diagnostic cutpoint of 6.5% was recommended based on the risk for developing microvascular complications such as retinopathy.
Better index of overall glycemic exposure & risk of complications Low intraindividual variability (<2%) No requirement for fasting or timed specimen Standardized methods with precision <2% Less affected by acute illness or stress Good stability after blood collection Single test can be used for both diagnosis and monitoring
Patients who have an HbA1c of 5.7 to 6.4% are considered at high risk for developing diabetes and cardiovascular disease in the future. These individuals are referred to as having prediabetes. They should be identified and counseled about lifestyle modifications such as exercise and weight loss. An elevated HbA1c should be confirmed with a repeat measurement on a different day, except in those individuals who are symptomatic and also have plasma glucose over 200 mg/dL. HbA1c testing is indicated in children in whom diabetes is suspected but the classic symptoms and a casual glucose >200 mg/dL are not found. Analysis should be performed on central laboratory instruments and not with point of care devices, which have not been shown to be sufficiently accurate or precise for diagnosis.
Test | Non-diabetes | Prediabetes | Diabetes |
HbA1c | 4.0 – 5.6% | 5.7 – 6.4% | 6.5% or > |
Fasting plasma glucose | <100 mg/dL | 100 – 125 mg/dL | 126 mg/dL or > |
2 hour glucose | <140 mg/dL | 140 – 199 mg/dL | 200 mg/dL or > |
The reference range of 4.0-5.6% was established in 1986 based on 124 nondiabetic individuals between the ages of 13 and 39 years of age. In 1994, the UK Prospective Diabetes Study found the upper limit of the reference range to be 5.4% in 195 healthy persons 25 to 65 years old and 5.6% in 53 healthy persons over 65 years of age.
Estimated Average Glucose Physicians often correlate the HbA1c level with a patient’s glucose meter history and fasting plasma glucose concentrations. The Diabetes Control and Complications Trial (DCCT) clearly demonstrated a direct relationship between HbA1c and mean plasma glucose levels (Diabetes Care 2002; 25:275-78).
Thus, HbA1c can be used to calculate the estimated average glucose (eAG). The following table summarizes the relationship.
HbA1c (%) | eAG (mg/dL) |
5 | 97 (76-120) |
6 | 126 (100-152) |
7 | 154 (123-185) |
8 | 183 (147-217) |
9 | 212 (170-249) |
10 | 240 (193-282) |
11 | 269 (217-314) |
12 | 298 (240-347) |
Average glucose concentration is calculated from HbA1c concentration using the formula: eAG = (28.7 x %HbA1c) – 46.7. Each 1% change in HbA1c represents a change of approximately 30 mg/dl in plasma glucose. It is important to realize that this data is based on overall averages and may vary in individual patients.
- Reporting of the eAG at this time is still controversial and is not routinely offered by clinical laboratories at this time.
- Hemoglobin A1c and Microvascular Complications Glycemic control is fundamental to diabetes management.
- HbA1c targets less than 7% reduce microvascular complications in type 1 and type diabetes when instituted early in the course of disease.
Hemoglobin A1c as a CV Risk Factor in Nondiabetic Individuals Macrovascular disease is the most important cause of mortality and morbidity in individuals with type 2 diabetes. Even when adjusted for conventional risk factors, diabetic individuals still exhibit a two-to-four-fold increased risk of cardiovascular disease in comparison to nondiabetic people.
Therefore, hyperglycemia is strongly suspected of promoting atherogenesis. Excess glucose is transformed into advanced glycation endproducts (AGEs) that not only make blood vessels inelastic and stenotic but also activates chronic inflammation. Some studies have demonstrated that HbA1c is also a predictor of all-cause, cardiovascular and ischemic heart disease mortality even at concentrations below the accepted threshold for diabetes (British Med J 2001; 322:15-18).
The following table lists the relative risk of death for each quartile of HbA1c concentration. HbA1c Concentration
Mortality | <5% | 5.0 – 5.4% | 5.5 – 6.9% | 7% or > |
All Cause | 1.0 | 1.41 | 2.07 | 2.64 |
CV | 1.0 | 2.53 | 2.46 | 5.04 |
Ischemic | 1.0 | 2.74 | 2.77 | 5.20 |
Individuals with HbA1c concentrations above 5% have greater risk than individuals with concentrations below 5%. Approximately 25% of population has HbA1c levels below 5% and 70% of the population had levels between 5 and 6.9%. HbA1c appears to resemble blood pressure and cholesterol in terms of its continuous relationship with cardiovascular risk.
- Two studies in the Annals of Internal Medicine have also validated that HbA1c is a progressive risk factor for CV disease in individuals with and without diabetes (Ann Intern Med 2004; 141:413-20 & 421-31).
- Every 1% absolute increase in HbA1c above the nonglycemic level of 5% predicts a 20% relative increase in the incidence of CV events even after adjustment for systolic blood pressure, cholesterol level, body mass index, waist to hip ratio, smoking and previous myocardial infarction or stroke.
A similar relationship exists for total mortality. Specimen requirement is one lavender top (EDTA) tube of blood.
Does an A1C of 6.9 require medication?
There is no specific A1c level that makes it necessary for you to be on medication. While an A1c of 6.5% or higher is indicative of diabetes, some people may need to start taking medication for an A1c under 6.5%. And others with an A1c over 6.5% aren’t prescribed any medication.
How much does A1C change in a year?
To determine whether FPG and 2-h postload glucose contribute to the increase in A1C observed with age, we analyzed FPG and 2-h postload glucose by age categories (supplemental Table A2, available in the online appendix). In nondiabetic subjects, we noted an ∼8 mg/dl rise in FPG in both FOS and NHANES and a 35 mg/dl rise in 2-h postload glucose in FOS. In FOS subjects with NGT, FPG increased minimally and 2-h postload glucose increased by 15 mg/dl with age. There was no difference in BMI noted across different age categories in either FOS or NHANES. In both the FOS and NHANES samples, there was a sex difference in the relationship between A1C and increasing age. We performed multivariate analyses to adjust for differences in sex, BMI, fasting glucose, and 2-h postload glucose. In FOS nondiabetic and NGT populations, the relationship between age and A1C remained unchanged in models adjusting for sex, BMI, fasting glucose, and 2-h postload glucose (supplemental Table A3a in the online appendix). Models adjusted for sex, BMI, and FPG in NHANES resulted in similar findings (supplemental Table A3b in the online appendix). From the above-mentioned multivariable linear regression models, every 1-year increase in age was associated with a 0.012-unit increase in A1C per year in the FOS and a 0.010-unit increase in the NHANES ( P < 0.001 for both) nondiabetic sample. Analyses of the FOS NGT subgroup (IFG and/or IGT excluded) showed a similar relationship between age and A1C (0.012-point A1C increase per year, P < 0.0001). The longitudinal analysis in FOS included a mean follow-up period of 6.7 years. An increase in A1C was observed in every age-group between examinations 5 and 7 in both the nondiabetic subjects and subjects with NGT ( Table 2 ) (paired t tests P < 0.0001). Mean increases in A1C of 0.024–0.043/year in each of the age-groups in nondiabetic subjects and 0.020–0.045/year in subjects with NGT over the 6.7-year period were observed.
Why do I have A1C every 3 months?
What is a hemoglobin A1C (HbA1C) test? – A hemoglobin A1C (HbA1C) test is a blood test that shows what your average blood sugar (glucose) level was over the past two to three months. Glucose is a type of sugar in your blood that comes from the foods you eat.
- Your cells use glucose for energy.
- A hormone called insulin helps glucose get into your cells.
- If you have diabetes your body doesn’t make enough insulin, or your cells don’t use it well.
- As a result, glucose can’t get into your cells, so your blood sugar levels increase.
- Glucose in your blood sticks to hemoglobin, a protein in your red blood cells.
As your blood glucose levels increase, more of your hemoglobin will be coated with glucose. An A1C test measures the percentage of your red blood cells that have glucose-coated hemoglobin. An A1C test can show your average glucose level for the past three months because:
- Glucose sticks to hemoglobin for as long as the red blood cells are alive.
- Red blood cells live about three months.
High A1C levels are a sign of high blood glucose from diabetes. Diabetes can cause serious health problems, including heart disease, kidney disease, and nerve damage, But with treatment and lifestyle changes, you can control your blood glucose levels. Other names: HbA1C, A1C, glycohemoglobin, glycated hemoglobin, glycosylated hemoglobin
Is an A1C of 5.8 OK?
What does an A1c level of 5.8 mean? Are there any symptoms associated with this level? – An A1c level of 5.8 means that 5.8% of the hemoglobin in your blood is saturated with sugar. An A1c of 5.8 is considered elevated and means your blood sugar levels have been raised over the last few months.
Elevated A1c levels of 5.7-6.4 percent are considered prediabetes. The higher your A1c, the greater your risk for developing diabetes. If your A1c is elevated, diet and lifestyle changes may be effective for getting your levels back into the optimal range without the need for medications. Lowering your A1c back into the optimal range (4-5.6%) can prevent or delay diabetes in the future.
An A1c of 5.8 doesn’t usually have any symptoms. One possible sign of prediabetes is a darkening of the skin and sometimes skin tags on certain parts of the body including the neck, armpits, elbows, knuckles, and knees. It’s important to know the symptoms of diabetes.
Can A1C change drastically?
A1C levels can fluctuate because of vitamin deficiencies, supplements, stress, lack of sleep, and more. If you’ve lived with type 2 diabetes for a while, you might be a pro at managing your blood sugar levels, You may know that it’s a good idea to limit carbs, exercise regularly, check other medications for possible interactions, and avoid drinking alcohol on an empty stomach.
- By now, you may be well attuned to how your day-to-day activities impact your blood sugar.
- So, if you see a big shift in your hemoglobin A1c (HbA1c) levels that you can’t explain, you might be surprised or frustrated.
- Sometimes, things you may not even think about can affect your blood sugar, which can lead to serious complications, such as heart attacks, kidney disease, blindness, or amputation,
Learning to recognize behaviors and circumstances that you don’t usually associate with blood glucose fluctuations may help you prevent more serious health concerns now and in the future.
How much will metformin lower A1C in 3 months?
How long does it take Metformin to work? – Metformin signals the liver to stop making blood sugar and releasing it into the circulation. This results in lower blood sugar level. Metformin improves how your muscles use insulin making this process much more efficient. How Long does Metformin Stay in your System?
Why didn t my A1C go down?
7. Your treatment may no longer be effective. – Because type 2 diabetes is a chronic disease, it’s likely that your treatment will need to change over time to effectively manage it, Lenhard says. An A1C that’s higher than your target may be a sign that your current treatment plan isn’t working as well as it should.
- If your doctor currently has you managing your A1C with diet and exercise, it may be time to consider adding a prescription medication designed to lower A1C or improve how your body processes insulin, Lenhard notes.
- If you’re on an oral medication and it’s not as effective as it once was, you may need to try another one or change your dose, says Lenhard.
Your doctor may also prescribe insulin or non-insulin injectables to help control your blood sugar. Once you’re on a new treatment, be sure to follow the doctor-prescribed regimen, as that’s the only way the medications will work to control your A1C, he says.
Can A1C change drastically?
A1C levels can fluctuate because of vitamin deficiencies, supplements, stress, lack of sleep, and more. If you’ve lived with type 2 diabetes for a while, you might be a pro at managing your blood sugar levels, You may know that it’s a good idea to limit carbs, exercise regularly, check other medications for possible interactions, and avoid drinking alcohol on an empty stomach.
By now, you may be well attuned to how your day-to-day activities impact your blood sugar. So, if you see a big shift in your hemoglobin A1c (HbA1c) levels that you can’t explain, you might be surprised or frustrated. Sometimes, things you may not even think about can affect your blood sugar, which can lead to serious complications, such as heart attacks, kidney disease, blindness, or amputation,
Learning to recognize behaviors and circumstances that you don’t usually associate with blood glucose fluctuations may help you prevent more serious health concerns now and in the future.
How much does A1C change in a year?
To determine whether FPG and 2-h postload glucose contribute to the increase in A1C observed with age, we analyzed FPG and 2-h postload glucose by age categories (supplemental Table A2, available in the online appendix). In nondiabetic subjects, we noted an ∼8 mg/dl rise in FPG in both FOS and NHANES and a 35 mg/dl rise in 2-h postload glucose in FOS. In FOS subjects with NGT, FPG increased minimally and 2-h postload glucose increased by 15 mg/dl with age. There was no difference in BMI noted across different age categories in either FOS or NHANES. In both the FOS and NHANES samples, there was a sex difference in the relationship between A1C and increasing age. We performed multivariate analyses to adjust for differences in sex, BMI, fasting glucose, and 2-h postload glucose. In FOS nondiabetic and NGT populations, the relationship between age and A1C remained unchanged in models adjusting for sex, BMI, fasting glucose, and 2-h postload glucose (supplemental Table A3a in the online appendix). Models adjusted for sex, BMI, and FPG in NHANES resulted in similar findings (supplemental Table A3b in the online appendix). From the above-mentioned multivariable linear regression models, every 1-year increase in age was associated with a 0.012-unit increase in A1C per year in the FOS and a 0.010-unit increase in the NHANES ( P < 0.001 for both) nondiabetic sample. Analyses of the FOS NGT subgroup (IFG and/or IGT excluded) showed a similar relationship between age and A1C (0.012-point A1C increase per year, P < 0.0001). The longitudinal analysis in FOS included a mean follow-up period of 6.7 years. An increase in A1C was observed in every age-group between examinations 5 and 7 in both the nondiabetic subjects and subjects with NGT ( Table 2 ) (paired t tests P < 0.0001). Mean increases in A1C of 0.024–0.043/year in each of the age-groups in nondiabetic subjects and 0.020–0.045/year in subjects with NGT over the 6.7-year period were observed.
Why HbA1c after 3 months?
What is a hemoglobin A1C (HbA1C) test? – A hemoglobin A1C (HbA1C) test is a blood test that shows what your average blood sugar (glucose) level was over the past two to three months. Glucose is a type of sugar in your blood that comes from the foods you eat.
- Your cells use glucose for energy.
- A hormone called insulin helps glucose get into your cells.
- If you have diabetes your body doesn’t make enough insulin, or your cells don’t use it well.
- As a result, glucose can’t get into your cells, so your blood sugar levels increase.
- Glucose in your blood sticks to hemoglobin, a protein in your red blood cells.
As your blood glucose levels increase, more of your hemoglobin will be coated with glucose. An A1C test measures the percentage of your red blood cells that have glucose-coated hemoglobin. An A1C test can show your average glucose level for the past three months because:
- Glucose sticks to hemoglobin for as long as the red blood cells are alive.
- Red blood cells live about three months.
High A1C levels are a sign of high blood glucose from diabetes. Diabetes can cause serious health problems, including heart disease, kidney disease, and nerve damage, But with treatment and lifestyle changes, you can control your blood glucose levels. Other names: HbA1C, A1C, glycohemoglobin, glycated hemoglobin, glycosylated hemoglobin
Why does HbA1c occur every 3 months?
What does HbA1c mean? – HbA1c is what’s known as glycated haemoglobin. This is something that’s made when the glucose (sugar) in your body sticks to your red blood cells. Your body can’t use the sugar properly, so more of it sticks to your blood cells and builds up in your blood.
Red blood cells are active for around 2-3 months, which is why the reading is taken quarterly. A high HbA1c means you have too much sugar in your blood. This means you’re more likely to develop diabetes complications, like serious problems with your eyes and feet. Knowing your HbA1c level and what you can do to lower it will help you reduce your risk of devastating complications.
This means getting your HbA1c checked regularly. It’s a vital check and part of your annual review, You’re entitled to get this test at least once a year. But if your HbA1c is high or needs a little more attention, it’ll be done every three to six months.