How Long Does Hydroxyzine Stay In Your System
How long do hydroxyzine’s effects last? And how long does it stay in your system? – Hydroxyzine is a type of drug called an antihistamine, It works by attaching to histamine receptors (binding sites) in your body. This produces a calming effect that helps relieve anxiety and itching.

  1. You may continue to have these effects from hydroxyzine for several hours after you take the drug.
  2. Hydroxyzine’s half-life can be used to figure out how long the drug stays in your system.
  3. The half-life of a drug is the time it takes for half of a drug’s dose to leave your body.
  4. Hydroxyzine’s half-life is about 14 hours.

So it takes about 14 hours for your body to get rid of half of a dose of hydroxyzine. Typically, it takes about five half-lives for a drug to completely leave your system. For hydroxyzine, this means the drug will stay in your system for about 70 hours after your last dose.

Does hydroxyzine make you sleepy the next day?

Hydroxyzine side effects – For some people, hydroxyzine side effects, which vary from mild to severe, can be unwelcome. When using hydroxyzine for sleep, common side effects include drowsiness, fatigue, nausea, dry mouth, and headache. Sometimes hydroxyzine makes people feel groggy, and they experience daytime sleepiness from its persistent effects after sleep.

  • Although this sedating effect is usually transient with regular or reduced usage, some people have reported that hydroxyzine leaves them feeling perpetually fatigued.
  • Using hydroxyzine for sleep also can make you feel nauseous.
  • Side effects like dry mouth and headaches are typically mild and short-lived, disappearing after a few days.

More severe hydroxyzine side effects include chest pain, severe headache, hallucinations and trauma nightmares, severe grogginess, respiratory depression, over-sedation and confusion in the elderly, and fainting. In the case of a hydroxyzine overdose, seizures may result.

  1. To avoid complications or serious side effects, do not take additional sleep-inducing substances when using hydroxyzine for sleep.
  2. Always pay attention to how your body reacts the first few times you take any prescription medication, including hydroxyzine.
  3. If you experience any persistent, mild side effects or any severe side effects, consult your doctor for medical advice.

Minded consumers also can reach out to our Care Team with any questions or concerns regarding the side effects of using hydroxyzine for sleep.

How long does hydroxyzine last for anxiety?

How long does hydroxyzine last for anxiety? – The effects of hydroxyzine typically last 3 to 4 hours. ‍

What happens if you suddenly stop taking hydroxyzine?

Safe Withdrawal from Hydroxyzine at Northpoint Washington – If you or someone you know is struggling with a dependence on hydroxyzine, it’s important to know that help is available. Detoxification is the first step in withdrawal from hydroxyzine. Our medical professionals and recovery specialists work hard to ensure every person safely detoxes from the drug.

Withdrawal from hydroxyzine can be difficult, and our experienced staff is here to help our clients through every step. We will work with you to create a personalized detox plan that considers your unique needs and situation. If you or someone you know is struggling with hydroxyzine, please call us at,

We are here to help you through every step of your recovery. : Dealing with Withdrawals from Hydroxyzine

When does hydroxyzine peak?

Hydroxyzine (Atarax, Vistaril) – Hydroxyzine is an antihistamine with weak sedative, anticholinergic, and antiemetic properties. It produces sedation by inhibiting the hypothalamic H-1 histamine receptors involved in governing the sleep-wake cycle in humans.28 The antimuscarinic action of hydroxyzine inhibits the flow of saliva, resulting in various degrees of xerostomia.

Although clinical anxiolysis is sometimes reported with hydroxyzine, this effect is most likely related to the production of drowsiness and is not linked to specific actions on the neural substrates involved in anxiety. In normal doses, it has no cardiovascular or respiratory depressant effects. Absorption through the gastrointestinal tract is relatively rapid, with the onset of action occurring in 15 to 30 minutes.

Peak levels occur at 2 hours. Recovery is slow by modern standards, reflected by the mean half-life of 3 hours. It is available in two forms, hydroxyzine hydrochloride (Atarax) and hydroxyzine pamoate (Vistaril). Preparation: tablets, elixir Dosage: 0.5 to 1.0 mg/kg Side effects: prolonged drowsiness, ataxia, dry mouth.

Is it hard to wake up with hydroxyzine?

Hydroxyzine is listed in the American Geriatric Society Beers Criteria as a potentially inappropriate medication to avoid in older adults due to common side effects involving the central nervous system such as drowsiness, dizziness, and cognitive dysfunction which may linger into the following morning recognized as ‘

You might be interested:  How Many Calories In A Teaspoon Of Sugar?

Do you get good sleep on hydroxyzine?

How Quickly Does Hydroxyzine Work? – Hydroxyzine benefits are felt quickly, usually within 15-30 minutes, If you are taking it to help you sleep, you should take it when you are ready for bed. It reaches peak levels after 2 hours, and most effects are no longer noticeable by 4-6 hours.

Does hydroxyzine calm your mind?

Hydroxyzine for Anxiety – Hydroxyzine is a first-generation antihistamine that has been used for many years. Histamine is a chemical that your body releases as part of its immune response, which then stimulates histamine receptors. When histamine receptors are stimulated, it can cause symptoms like:

Anxiety, panic attacks, and tensionFlushing from the dilation of veinsCoughingLung and gastrointestinal contraction (such as asthma, intestinal cramping, or diarrhea)Hives, rashes, and other anaphylaxis symptoms

Because it is an antihistamine, hydroxyzine suppresses the effects of histamine. It is prescribed for:

Itching from hives or contact dermatitisSymptoms of anxiety, including generalized anxiety disorder (GAD)TensionPanic attacksSedation before general anesthesia

Hydroxyzine is in the same class of drugs as diphenhydramine (Benadryl), which is also a first-generation antihistamine, and cetirizine (Zyrtec), which is a second generation H-1 antihistamine that works in a similar way. All these medications act on H-1 histamine receptors. H-1 receptors are found all over the body, including:

Uterine liningCentral nervous system (CNS)Cardiac tissueGastrointestinal tissuesVascular cellsSmooth muscle of the lungsImmune cells

Hydroxyzine is not typically used long-term for anxiety, but may be prescribed as a way to relieve symptoms while longer-acting medications become effective. It may also be used for people who do not have chronic anxiety, but only need occasional relief during stressful moments or episodes.

  • By blocking the effect of histamine, it can decrease the anxiety-related effect that too much histamine can stimulate.
  • Hydroxyzine, unlike other antihistamines, also affects serotonin, a brain chemical that helps with feelings of calm, stability, and balance.
  • Because hydroxyzine can help your brain retain more serotonin, it might have a longer effect on feelings of anxiety and mood.

If insomnia or sleep problems are related to anxiety, hydroxyzine may be doubly impactful by having a sleep-inducing effect while also supporting serotonin levels.

Can I take hydroxyzine every night for anxiety?

Hydroxyzine for anxiety dosage Even if hydroxyzine is the only anxiety medication you take, it’s not a long-term option. More commonly, it’s prescribed short-term, along with another longer-term anxiety medication like Buspar or Celexa that’s taken every day.

Does hydroxyzine calm nerves?

Descriptions – Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses).

  • Tablet
  • Syrup
  • Capsule

Can you take hydroxyzine permanently?

Hydroxyzine is intended for short-term use only (less than 4 months) when used to treat anxiety. Using hydroxyzine long-term would be considered an off-label use for the drug because there are no studies looking at the long-term effects of hydroxyzine.

Some research suggests a link between long-term use of medications with anticholinergic properties, such as hydroxyzine, and dementia, particularly in older adults. Brain fog has also been reported with long-term use. Other conditions that hydroxyzine may be prescribed for, such as itchy skin due to an allergy, hives, dermatitis, or eczema, or as a sedative before surgery or other procedures, are generally short-lived and there is no need to prescribe hydroxyzine long-term.


Cai X, Campbell N, Khan B, Callahan C, Boustani M. Long-term anticholinergic use and the aging brain. Alzheimer’s Dement.2013;9(4):377-385. doi:10.1016/j.jalz.2012.02.005 Hydroxyzine Updated 07/2020. Greenstone LLC.

Can I take hydroxyzine forever?

The lowdown – Hydroxyzine can have a sedative effect and help you sleep. However, it is not typically prescribed to treat primary insomnia, It may be used to treat anxiety, which can cause insomnia and is known to help with sleep disturbances caused by PTSD or cirrhosis.

Is it bad to take hydroxyzine everyday?

Are There Any Risks For Taking Hydroxyzine For Long Periods Of Time? To date, there are no known problems associated with the long-term use of hydroxyzine. It is a safe and effective medication when used as directed. A physician should reassess periodically the usefulness of the drug for the individual patient.

Does hydroxyzine stop panic attacks?

Successful Treatment With Hydroxyzine of Acute Exacerbation of Panic Disorder in a Healthy Man: A Case Report To the Editor: In a given year, approximately 6 million American adults aged 18 years or older have panic disorder., To the best of our knowledge, this is the first report to document the successful treatment of acute exacerbation of panic disorder with hydroxyzine in a healthy adult.

Case report. Mr A, a 25-year-old man with a history of panic disorder, presented in 2010 to the emergency department complaining of chest pain, tachycardia, palpitations, hyperventilation, shortness of breath, sweating, nausea, and vomiting. Moreover, he reported derealization, a sense of doom, and constant fear of having another panic attack.

Mr A stated that he had been having panic attacks about 3 or 4 times daily for the previous week. Myocardial infarction was ruled out. Blood workup was inconclusive for any other medical cause. Mr A had been on venlafaxine 75 mg/d orally for the previous 6 months.

You might be interested:  How To Say Nice To Meet You In Spanish?

He had taken paroxetine 40 mg/d orally with no improvement for the 6 months prior to starting venlafaxine. Past medical, surgical, and family histories were not significant for any major illnesses. He was employed and single and smoked half a pack of cigarettes daily, but had no history of alcohol or illegal drug use.

The patient denied having any psychosocial stressors. Physical examination findings revealed no abnormalities. Mr A was admitted to the acute psychiatry unit for observation. Upon admission to the unit, hydroxyzine 25 mg 3 times daily was started with no other changes in medication or therapy.

The patient received prompt relief, and there were no further panic attacks during his 3-day admission or his 1-month follow-up. To the best of our knowledge, there are no published cases of successful treatment of acute exacerbation of panic disorder with hydroxyzine in healthy adults. There has been clear evidence of the anxiolytic efficacy of hydroxyzine.

In a controlled trial in generalized anxiety disorder patients, hydroxyzine demonstrated greater and more rapid cognitive improvement compared to lorazepam. Moreover, it has also shown a lack of organ toxicity and an absence of dependency. As reported in our case, an acute exacerbation of panic disorder was effectively managed by hydroxyzine in a healthy adult.

If practitioners recognize this association, extensive use of benzodiazepines may be prevented.1. Kessler R.C, Chiu W.T, Demler O, et al. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry.2005; 62 (6):617–627.2. US Census Bureau Population Estimates by Demographic Characteristics.

Annual Estimates of the Population by Selected Age Groups and Sex for the United States: April 1, 2000 to July 1, 2004 (NC-EST2004–02). Population Division, US Census Bureau Release Date: June 9, 2005. Accessed February 24, 2011.3. Ferreri M, Hantouche E.G.

Can hydroxyzine make you more anxious?

A small number of people who take diphenhydramine experience a faster heart rate, trouble sleeping, and restlessness. One study also suggests cetirizine and hydroxyzine have a greater chance of causing anxiety and mood changes than other antihistamines. Hydroxyzine can also be used to treat anxiety conditions.

What should I avoid while taking hydroxyzine?

Opioids, sedatives, and alcohol can make hydroxyzine side effects more intense. These include drowsiness and confusion. Hydroxyzine also interacts with amiodarone, antipsychotics, and some antibiotics. These medications may raise the risk of serious heart rhythm changes.

Can you drink alcohol while taking hydrOXYzine?

There is 1 alcohol/food/lifestyle interaction with hydroxyzine. Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment.

  • You should avoid or limit the use of alcohol while being treated with hydrOXYzine.
  • Do not use more than the recommended dose of hydrOXYzine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.
  • Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

What does hydrOXYzine feel like?

Hydroxyzine Abuse, Dependence and Addiction – Hydroxyzine has effective anxiolytic, hypnotic and sedative properties. It can induce feelings of relaxation and euphoria. On top of being versatile, this medication does not share any of the abuse, addiction or dependence potentials that come with other similar drugs.

  1. This is one of the primary reasons why this medication is extremely appealing to patients since a hydroxyzine high is not going to be too addictive.
  2. Many patients whether hydroxyzine high will lead to abuse and dependence.
  3. It is possible, although the demographics that tend to fall victim to hydroxyzine abuse are teenagers.

To get a better idea of how others have reacted to hydroxyzine, check out Erowid for hydroxyzine, Atarax, hydroxyzine pam and Vistaril. This website provides a collection of reports on various experiences others have had with hydroxyzine. It tells you whether they’ve gotten an Atarax high, or whether they felt nothing at all.

How do you know if hydroxyzine is working?

Hydroxyzine (Vistaril) is an antihistamine that can treat anxiety and itching due to allergies. It typically starts working within 30 minutes of taking a dose. Drowsiness is a common side effect of hydroxyzine, so it’s sometimes prescribed off-label for sleep.

Can hydroxyzine cause depression?

There are 9 disease interactions with hydroxyzine.

  • Depression
  • QT prolongation
  • Anticholinergic effects
  • Asthma/COPD
  • Cardiovascular
  • Renal/liver disease
  • Glaucoma
  • Liver disease
  • Renal/liver disease

A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of most anxiolytics, sedatives and hypnotics. Some of these changes include decreased inhibition, aggressiveness, agitation, and hallucinations.

Why does hydroxyzine make me tired for days?

As an antihistamine, hydroxyzine blocks the effects of histamine in your body, which makes you sleepy. (Think about how you feel after taking Benadryl or Nyquil.) Serotonin is a chemical that affects your mood. Hydroxyzine’s unique effect on serotonin is likely why it’s the only antihistamine used for anxiety.

Is grogginess a side effect of hydroxyzine?

Precautions – It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Call your doctor if your symptoms do not improve or if they get worse.

You might be interested:  How Long Is A Flight To Hawaii From Chicago?

Make sure your doctor knows if you are pregnant. Do not use this medicine during the early part of a pregnancy unless your doctor tells you to. This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert).

Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

  1. Check with your doctor before taking any of the above while you are using this medicine.
  2. Contact your doctor right away if you have any changes to your heart rhythm.
  3. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat.
  4. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

This medicine may cause a serious skin condition called acute generalized exanthematous pustulosis (AGEP). Tell your doctor if you have a fever, skin rash, or worsening of skin problems after using this medicine. Do not take other medicines unless they have been discussed with your doctor.

Does hydroxyzine give you a hangover?

Discussion – The primary result of this study was that both levocetirizine monotherapy and therapy with levocetirizine plus hydroxyzine were similarly effective in reducing urticarial symptoms, reducing night-time sleep disturbances and improving QoL.

  • In contrast, daytime sedation was significantly less with levocetirizine monotherapy in comparison with levocetirizine plus hydroxyzine.
  • The effectiveness of levocetirizine in relieving the symptoms of CSU and improving QoL confirms previous findings.14, 16 – 18 It is of particular relevance in this study that the subjective element of the UAS, the severity of pruritus, was similarly reduced by both treatment regimens, suggesting that the central effects of hydroxyzine do not contribute to the overall antipruritic effect, which is agreement with the hypothesis that histamine is involved primarily in the peripheral genesis of itch.19 Furthermore, both treatment regimens having a similar effect in reducing night-time sleep disturbances again indicates that it is the peripheral antipruritic effect of the nonsedating second-generation H 1 -antihistamine that is of prime importance rather than any central sedative effects.

What is very clear from this study is that patients receiving levocetirizine monotherapy were significantly less sedated during the day than they were before treatment at the beginning of the study, confirming the findings of Staevska et al,14 In contrast, when treated with levocetirizine plus hydroxyzine, patients experienced a similar level of sedation to those who were not treated.

Furthermore, patients receiving levocetirizine monotherapy experienced less daytime sedation than those receiving levocetirizine plus hydroxyzine. This strongly suggests that the detrimental sedative effects of hydroxyzine were due to its prolonged central nervous system effects. With a terminal half life of 20–25 h, 20 it is not surprising that hydroxyzine has hangover effects into the next day.

We believe that this study has two weaknesses. Firstly, we did not perform objective assessments of alertness or productivity. Even so, our study would support the conclusion of Murota et al,21 that pruritic diseases negatively impact on daily activity and impair productivity, and that this is improved in patients taking second-generation nonsedative, but not first-generation sedative, H 1 -antihistamines, and that the improvements correlated with the alleviation of itch and improved QoL.

The second weakness is that the length of the study, 10 days, is less than that of many similar studies in urticaria. This was because the study was performed at a tertiary referral clinic with patients from all over Bulgaria and we wanted to ensure a sustainable follow-up of patients, particularly given compliance issues.

In conclusion, the results of this study do not support the widely held belief that the most effective treatment for chronic urticaria is a nonsedating second-generation H 1 -antihistamine in the morning and a sedating first-generation H 1 -antihistamine, usually hydroxyzine, at night to enhance sleep.

Can hydroxyzine cause brain fog?

Hydroxyzine is intended for short-term use only (less than 4 months) when used to treat anxiety. Using hydroxyzine long-term would be considered an off-label use for the drug because there are no studies looking at the long-term effects of hydroxyzine.

  • Some research suggests a link between long-term use of medications with anticholinergic properties, such as hydroxyzine, and dementia, particularly in older adults.
  • Brain fog has also been reported with long-term use.
  • Other conditions that hydroxyzine may be prescribed for, such as itchy skin due to an allergy, hives, dermatitis, or eczema, or as a sedative before surgery or other procedures, are generally short-lived and there is no need to prescribe hydroxyzine long-term.


Cai X, Campbell N, Khan B, Callahan C, Boustani M. Long-term anticholinergic use and the aging brain. Alzheimer’s Dement.2013;9(4):377-385. doi:10.1016/j.jalz.2012.02.005 Hydroxyzine Updated 07/2020. Greenstone LLC.